Bupropion and Iron for Restless Leg Syndrome: Do They Have Efficacy Similar to Ropinirole?

Sir, I read with great interest the review article on Lhermitte’s sign by Khare and Seth.[1] The sign occurs, inter alia, in multiple sclerosis, in traumatic lesions of the cervical cord, and in subacute combined degeneration. I agree that very few studies are available on Lhermitte’s sign and there is need of more research in this particular field. In this current review, treatment with extracranial picotesla range pulsed electromagnetic fields was said to be effective. Neck brace and collar might also be prescribed by physical therapists, and exercises and relaxation technique were claimed to be helpful.